Description

1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]- is a high-purity nucleoside analog derivative with a complex stereochemistry, making it a critical building block for advanced pharmaceutical research. This compound is valued for its role as a key synthetic intermediate in the development of novel antiviral and anticancer therapeutics. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of modified nucleosides and nucleotide-based drugs. The precise stereochemistry at multiple centers is essential for its biological activity and integration into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of experimental antiviral and anticancer agents.
• Nucleoside Analog Research: Used in academic and industrial R&D to study structure-activity relationships (SAR) and develop new bioactive molecules.
• Antiviral Drug Development: A potential building block for novel compounds targeting viral polymerases and replication mechanisms.
• Oncology Research: Investigated for incorporation into nucleotide-based prodrugs designed to inhibit cancer cell proliferation.
• Biochemical Tool Compound: Employed in enzymatic studies to understand substrate specificity and inhibition.
• Process Chemistry & Scale-Up: Used in developing and optimizing synthetic routes for Good Manufacturing Practice (GMP) production.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]-
CAS No.	222631-73-4
Molecular Formula	C12H15N3O5
Molecular Weight	281.26 g/mol
Synonyms	7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-methylpyrrolidin-2-yl]-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione; (2S,3S,4R,5R)-2-(2,4-Dioxo-3,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-methylpyrrolidine-3,4-diol; Nucleoside analog intermediate; Pyrrolopyrimidinedione derivative.
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione derivative is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral methods to confirm stereochemical integrity, ensuring compliance with research-grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept in a desiccated environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.