Description

1H-Pyrrolo3,2-Dpyrimidine-2,4(3H,5H)-Dione, 7-(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl- is a high-purity, chiral pyrrolopyrimidinedione derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a sophisticated building block for the synthesis of complex molecules, particularly nucleoside analogs and enzyme inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel antiviral and anticancer nucleoside analogs.
• Enzyme Inhibitor Synthesis: Used as a core scaffold for designing and synthesizing potent inhibitors targeting specific kinases and other enzymes.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the biological activity and pharmacokinetic properties of lead compounds.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.
• Biochemical Tool Compound: Utilized in biochemical assays to study cellular pathways and mechanisms of action.
• Academic Research: A valuable compound for universities and research institutes exploring new synthetic methodologies and bioorganic chemistry.

Basic Information

Item	Detail
Product Name	1H-Pyrrolo3,2-Dpyrimidine-2,4(3H,5H)-Dione, 7-(2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)-2-Pyrrolidinyl-
CAS No.	222631-71-2
Molecular Formula	C11H13N3O5
Molecular Weight	267.24 g/mol
Synonyms	7-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-pyrrolo[3,2-d]pyrimidine-2,4-dione; (2R,4S,5R)-2-(2,4-Dioxo-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)oxolane-4-ol; Pyrrolopyrimidinedione nucleoside analog; Chiral pyrrolo[3,2-d]pyrimidine derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality systems. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We employ validated analytical methods, including HPLC, chiral HPLC, and NMR, to ensure the identity and quality meet the exacting standards required for pharmaceutical research. Specifications are designed to be compliant with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.