Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,5-dihydro- is a sophisticated nucleoside analogue derivative with significant potential in advanced pharmaceutical research and development. This compound matters as a key chiral building block for the synthesis of novel antiviral and anticancer agents, offering a unique structural motif for targeting specific enzymatic pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery of next-generation therapeutics, particularly those focused on nucleoside-based drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel nucleoside analogue drugs targeting viral infections and oncology.
• Antiviral Drug Research: Used in R&D for developing therapeutics against viruses that utilize nucleoside metabolism, such as hepatitis and herpes viruses.
• Anticancer Agent Development: Investigated as a building block for prodrugs designed to inhibit cancer cell proliferation by interfering with DNA/RNA synthesis.
• Biochemical Tool Compound: Employed in enzymatic studies to understand the mechanism of action of nucleoside-processing enzymes.
• Medicinal Chemistry Library Synthesis: A valuable scaffold for creating diverse chemical libraries for high-throughput screening in drug discovery programs.
• Process Chemistry & Scale-up: Used in developing and optimizing synthetic routes for the commercial production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,5-dihydro-
CAS No.	222631-67-6
Molecular Formula	C12H14N4O4S
Molecular Weight	310.33 g/mol
Synonyms	7-[(2S,3S,4R,5S)-3,4-Dihydroxy-5-(mercaptomethyl)-2-pyrrolidinyl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; (2S,3S,4R,5S)-2-(4-Oxo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(mercaptomethyl)pyrrolidine-3,4-diol; Mercaptopurine nucleoside analogue; Thionucleoside derivative; Pyrrolopyrimidine nucleoside; CAS 222631-67-6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, NMR, and MS to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles are available upon request. Our quality management system supports development under cGMP guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This compound is easily oxidized and light-sensitive. Keep container tightly sealed in a dry and well-ventilated place. Avoid exposure to moisture and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.