Description

1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]-2-pyrrolidinyl]-, diammonium salt is a high-purity, nucleoside-derived chemical building block of significant interest in advanced pharmaceutical research. This compound serves as a critical synthetic intermediate for the development of novel antiviral and anticancer therapeutics, particularly those targeting nucleotide metabolism. It is essential for research and development laboratories in the pharmaceutical and biotechnology sectors focused on nucleoside analog synthesis. The diammonium salt form enhances its stability and solubility for precise formulation work.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog drugs with potential antiviral or anticancer activity.
• Antiviral Drug Research: Used in R&D for developing therapeutics that mimic natural nucleotides to inhibit viral polymerase enzymes.
• Oncology Research: Investigated as a building block for antimetabolite chemotherapeutic agents that disrupt DNA/RNA synthesis in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor for studies involving kinases and other nucleotide-processing enzymes.
• Process Chemistry & Scale-Up: Serves as a starting material for process optimization and the commercial-scale production of active pharmaceutical ingredients (APIs).
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]-2-pyrrolidinyl]-, diammonium salt
CAS No.	222631-60-9
Molecular Formula	C11H20N6O9P
Molecular Weight	420.29 g/mol
Synonyms	7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-((phosphonooxy)methyl)pyrrolidin-2-yl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione diammonium salt; (2S,3S,4R,5R)-2-(2,4-Dioxo-3,4-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-((phosphonooxy)methyl)pyrrolidine-3,4-diol diammonium salt; Toyocamycin 5'-monophosphate diammonium salt; Toyocamycin phosphate diammonium salt; Nucleoside antibiotic intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione diammonium salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and potency. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.