Description

5H-Pyrrolo3,2-Dpyrimidine, 7-Bromo-5-(1,1-Dimethylethyl)Dimethylsilyl-2,4-Bis(Phenylmethoxy)- is a sophisticated, multi-functionalized heterocyclic building block of significant interest in advanced organic synthesis. Its complex structure, featuring bromine and silyl protecting groups, makes it a critical intermediate for constructing complex molecular architectures with high precision. This compound is primarily utilized by pharmaceutical R&D and fine chemical organizations engaged in the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of nucleoside analogs, kinase inhibitors, and other targeted therapeutic agents.
• Organic Synthesis Building Block: Used in cross-coupling reactions (e.g., Suzuki, Stille) and other metal-catalyzed transformations to introduce complex pyrrolopyrimidine scaffolds.
• Agrochemical Research: Employed in the development of new herbicides and fungicides that require specific heterocyclic cores for bioactivity.
• Material Science: Potential use in the synthesis of organic semiconductors or ligands for catalytic systems due to its electron-rich aromatic system.
• Academic & Contract Research: A valuable reagent for methodological studies and the construction of compound libraries for high-throughput screening.

Basic Information

Item	Detail
Product Name	5H-Pyrrolo3,2-Dpyrimidine, 7-Bromo-5-(1,1-Dimethylethyl)Dimethylsilyl-2,4-Bis(Phenylmethoxy)-
CAS No.	222631-57-4
Molecular Formula	C25H31BrN2O2Si
Molecular Weight	499.52 g/mol
Synonyms	7-Bromo-5-(tert-butyldimethylsilyl)-2,4-bis(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidine; 7-Bromo-5-(TBDMS)-2,4-bis-O-benzyl-5H-pyrrolo[3,2-d]pyrimidine; tert-Butyl[7-bromo-2,4-bis(phenylmethoxy)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]dimethylsilane; 5-(tert-Butyldimethylsilyl)-7-bromo-2,4-bis(benzyloxy)-5H-pyrrolo[3,2-d]pyrimidine; 7-Bromo-2,4-di-O-benzyl-5-(TBDMS)-5H-pyrrolo[3,2-d]pyrimidine; 222631-57-4; 5H-Pyrrolo[3,2-d]pyrimidine, 7-bromo-5-[(1,1-dimethylethyl)dimethylsilyl]-2,4-bis(phenylmethoxy)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols, ensuring batch-to-batch consistency and high purity essential for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged manipulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.