Description

4H-Pyrrolo3,2-Dpyrimidin-4-One, 7-(2S,3S,4R,5S)-5-(Fluoromethyl)-3,4-Dihydroxy-2-Pyrrolidinyl-1,5-Dihydro-, Monohydrochloride is a high-purity, fluorinated pyrrolopyrimidinone derivative of significant interest in advanced pharmaceutical research. This compound serves as a sophisticated chemical building block and key intermediate for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical R&D organizations and contract research and manufacturing (CRO/CMO) companies engaged in developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for antiviral and oncology targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Nucleoside/Nucleotide Analog Development: The structural motif is valuable for creating novel fluorinated analogs with potential therapeutic applications.
• Biochemical Tool Compound: Employed in biochemical assays to study enzyme inhibition and cellular pathways.
• Process Chemistry & Scale-Up: Serves as a key material for developing and optimizing robust, scalable synthetic routes for pilot and commercial manufacturing.

Basic Information

Product Name	4H-Pyrrolo3,2-Dpyrimidin-4-One, 7-(2S,3S,4R,5S)-5-(Fluoromethyl)-3,4-Dihydroxy-2-Pyrrolidinyl-1,5-Dihydro-, Monohydrochloride
CAS No.	222631-49-4
Molecular Formula	C11H14FN3O3 • HCl
Molecular Weight	291.71 g/mol (free base)
Synonyms	7-[(2S,3S,4R,5S)-5-(Fluoromethyl)-3,4-dihydroxy-2-pyrrolidinyl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; Fluoromethyl-dihydroxypyrrolidinyl pyrrolopyrimidinone hydrochloride; (2S,3S,4R,5S)-5-(Fluoromethyl)-3,4-dihydroxy-1-[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)]pyrrolidine-2-carboxamide hydrochloride (related isomer); CAS 222631-49-4; Pyrrolo[3,2-d]pyrimidin-4(5H)-one, 7-[5-(fluoromethyl)-3,4-dihydroxy-2-pyrrolidinyl]-1,5-dihydro-, monohydrochloride, (2S,3S,4R,5S)-
EINECS	Contact for details

Quality Control

Our 4H-Pyrrolo3,2-Dpyrimidin-4-One derivative is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR/IR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with ICH guidelines and customer-specific regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.