Description

3,4-Pyrrolidinediol, 2-(4-Amino-5H-Pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- is a high-purity, stereochemically defined nucleoside analog building block. This compound is of critical importance in the research and development of novel antiviral and anticancer therapeutics, serving as a key synthetic intermediate. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of modified nucleosides and nucleotide analogs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside-based antiviral agents targeting viral polymerases.
• Anticancer Drug Development: Used in research for creating nucleotide analogs that interfere with DNA/RNA synthesis in rapidly dividing cancer cells.
• Biochemical Research: Serves as a modified nucleoside substrate for studying enzyme mechanisms, such as those of kinases and polymerases.
• Prodrug Synthesis: Acts as a core structure for developing prodrugs with enhanced bioavailability and targeted delivery.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies to optimize potency and selectivity of therapeutic candidates.
• Labeled Compound Production: A starting material for synthesizing isotopically labeled (e.g., C13, N15) compounds for metabolic and pharmacokinetic studies.

Basic Information

Item	Details
Product Name	3,4-Pyrrolidinediol, 2-(4-Amino-5H-Pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)-
CAS No.	222631-44-9
Molecular Formula	C11H16ClN5O4
Molecular Weight	317.73 g/mol
Synonyms	(2S,3S,4R,5R)-2-(4-Amino-7H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride; 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine hydrochloride; 4-Amino-7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[3,2-d]pyrimidine hydrochloride; Nucleoside analog intermediate; Modified nucleoside HCl salt
EINECS	Contact for details

Quality Control

Our 3,4-Pyrrolidinediol, 2-(4-Amino-5H-Pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)-, monohydrochloride, (2S,3S,4R,5R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.