Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]-1,5-dihydro-, monohydrochloride is a high-purity, complex heterocyclic compound with significant pharmaceutical relevance. This monohydrochloride salt form offers enhanced stability and solubility, making it a critical building block for advanced research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents, particularly in antiviral and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of nucleoside analog drugs.
• Antiviral Drug Development: Serves as a core scaffold for investigating novel inhibitors targeting viral polymerases and replication enzymes.
• Oncology Research: Used in the synthesis of potential chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies and mechanism-of-action investigations.
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for Active Pharmaceutical Ingredient (API) manufacturing.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-methyl-2-pyrrolidinyl]-1,5-dihydro-, monohydrochloride
CAS No.	222631-37-0
Molecular Formula	C12H17ClN4O3
Molecular Weight	300.74 g/mol
Synonyms	7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-methyl-2-pyrrolidinyl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; (2S,3S,4R,5R)-5-Methyl-2-[4-oxo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-7-yl]pyrrolidine-3,4-diol hydrochloride; 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-methylpyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; Pyrrolopyrimidine nucleoside analog hydrochloride; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4H-Pyrrolo[3,2-d]pyrimidin-4-one derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory compliance and research reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.