Description

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-, monohydrochloride is a high-purity, chemically defined nucleoside analog derivative with significant pharmaceutical relevance. This compound is valued for its role as a critical intermediate or active pharmaceutical ingredient (API) in advanced therapeutic research and development. It is primarily sought by pharmaceutical companies and research institutions engaged in the synthesis of novel antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of nucleoside-based antiviral drugs.
• Antiviral Research: Used in the development and study of compounds targeting viral polymerases and replication mechanisms.
• Oncology Research: Serves as a precursor for potential chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Studies: Employed as a substrate or inhibitor in enzymatic assays to study metabolic pathways.
• Process Development: Utilized in scaling up and optimizing synthetic routes for complex active pharmaceutical ingredients (APIs).
• Reference Standard: Acts as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical manufacturing.

Basic Information

Product Name	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 1,5-dihydro-7-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-, monohydrochloride
CAS No.	222631-32-5
Molecular Formula	C11H15ClN4O3
Molecular Weight	286.72 g/mol
Synonyms	7-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride; (2R,3S,5R)-5-(4-Oxo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol hydrochloride; Nucleoside analog pyrrolopyrimidinone hydrochloride; Pyrrolo[3,2-d]pyrimidine nucleoside HCl; 7-(4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We offer material suitable for research and pharmaceutical development, with quality systems designed to meet GMP and ICH Q7 guidelines where applicable. Comprehensive analytical testing, including HPLC for purity and identity confirmation, is performed. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.