Description

Fmoc-1-Amino-1-Cyclooctanecarboxylic Acid CAS NO 222166-38-3 is a specialized, non-proteinogenic amino acid derivative featuring an eight-membered cyclooctane ring, protected with a fluorenylmethyloxycarbonyl (Fmoc) group on the amine functionality. This compound is critical for the synthesis of conformationally constrained peptides, enabling researchers to study and modulate peptide structure, stability, and biological activity. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutics, diagnostic agents, and chemical biology probes targeting proteases, GPCRs, and other protein-protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of peptides containing rigid, cyclooctane-based scaffolds.
• Medicinal Chemistry & Drug Discovery: Used to introduce conformational constraints into lead compounds, improving metabolic stability, potency, and selectivity against biological targets.
• Chemical Biology Research: Employed in the synthesis of peptide mimetics, enzyme inhibitors, and molecular probes to investigate protein function and signaling pathways.
• Peptidomimetic Development: Serves as a core component for creating non-natural peptide analogs with enhanced pharmacological properties.
• Bioconjugation & Labeling: The reactive carboxylic acid and protected amine allow for site-specific modification and labeling of biomolecules.
• Academic & Institutional Research: A valuable reagent for universities and research institutes studying peptide structure-activity relationships (SAR).

Basic Information

Product Name	Fmoc-1-Amino-1-Cyclooctanecarboxylic Acid
CAS No.	222166-38-3
Molecular Formula	C₂₄H₂₇NO₄
Molecular Weight	393.48 g/mol
Synonyms	Fmoc-Ac8c-OH; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]cyclooctane-1-carboxylic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-aminocyclooctane-1-carboxylic Acid; Fmoc-1-Amino-1-cyclooctanecarboxylic Acid; Fmoc-1-Aminocyclooctane-1-carboxylic Acid; N-Fmoc-1-aminocyclooctane-1-carboxylic Acid; 1-Amino-1-cyclooctanecarboxylic Acid Fmoc Derivative
EINECS	Contact for details

Quality Control

Our Fmoc-1-Amino-1-Cyclooctanecarboxylic Acid is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.