Description

Phrixotoxin-2 is a selective peptide toxin that potently inhibits acid-sensing ion channel 3 (ASIC3). This compound is a critical research tool for neuropharmacology, enabling the study of pain sensation, ischemic stroke, and other physiological processes mediated by ASIC channels. It is essential for academic research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neuroscience and novel analgesic development.

Application

• Neuroscience Research: A selective pharmacological tool for studying the function and modulation of Acid-Sensing Ion Channel 3 (ASIC3) in vitro and in vivo.
• Pain Pathway Investigation: Used to elucidate the role of ASIC3 in nociception, inflammatory pain, and chronic pain models.
• Cardiac Ischemia Studies: Applied in research exploring the involvement of ASIC3 channels in myocardial ischemia and related tissue injury.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screening assays for identifying new ASIC3 modulators or antagonists.
• Electrophysiology: A key reagent for patch-clamp experiments to characterize ASIC3 current properties and inhibition kinetics.
• Biochemical Assay Development: Used in the development and validation of binding assays and other biochemical tests targeting the ASIC3 receptor.

Basic Information

Product Name	Phrixotoxin-2
CAS No.	221889-63-0
Molecular Formula	C152H244N48O44S8
Molecular Weight	3463.3 g/mol
Synonyms	Phrixotoxin 2; PrTx2; ASIC3 Inhibitor, Phrixotoxin-2; μ-TRTX-Pc1a; Acid-sensing ion channel 3 inhibitor; Peptide toxin PcTx1 analogue; μ-TRTX-Pc1a
EINECS	Contact for details

Quality Control

Every batch of Phrixotoxin-2 is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research use. Our quality assurance includes comprehensive analytical testing via HPLC and mass spectrometry. A detailed Certificate of Analysis (COA), providing batch-specific data on purity, peptide content, and bioactivity, is supplied with each product to guarantee traceability and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Specified per batch (typically in nM range vs. ASIC3)
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.