Description

Fmoc-Dl-2-Amino-4-Pentenoic Acid is a protected, non-natural amino acid derivative featuring an Fmoc-protected amine and a reactive pentenyl side chain. This compound is a crucial chiral building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of structural diversity and functional handles into peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of custom peptides containing the non-proteinogenic 2-amino-4-pentenoic acid residue.
• Peptidomimetic Drug Discovery: Used to incorporate olefinic side chains into peptide backbones for structure-activity relationship (SAR) studies and the creation of metabolically stable analogs.
• Chemical Biology Probes: Serves as a precursor for synthesizing peptide-based probes, where the alkene group can be modified via click chemistry (e.g., thiol-ene, hydroamination) for labeling or conjugation.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Industrial Research: Fundamental research tool for studying peptide structure, function, and protein-protein interactions.

Basic Information

Product Name	Fmoc-Dl-2-Amino-4-Pentenoic Acid
CAS No.	221884-63-5
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.37 g/mol
Synonyms	Fmoc-2-Amino-4-pentenoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-amino-4-pentenoic acid; Fmoc-DL-2-Amino-4-pentenoic acid; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid; Fmoc-2-Amino-4-pentenoic acid, DL-; UNII-9F6K7J8F0I; 9F6K7J8F0I; N-Fmoc-2-amino-4-pentenoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-2-Amino-4-Pentenoic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is analyzed via HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.