Description

Phrixotoxin-1 is a selective peptide toxin that potently inhibits acid-sensing ion channels (ASICs), specifically targeting the ASIC1a subtype. This high-purity biochemical is essential for advanced neuroscience research and pharmacological development, providing a critical tool for studying pain signaling, neurological disorders, and ion channel function. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in neuropharmacology and ion channel discovery.

Application

• Neuroscience Research: A key pharmacological tool for studying the role of acid-sensing ion channels (ASICs) in synaptic transmission, neuronal excitability, and acidosis-related signaling.
• Pain Pathway Investigation: Used to elucidate mechanisms of inflammatory and ischemic pain by selectively blocking ASIC1a channels involved in nociception.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput assays for developing novel analgesics and neuroprotective agents.
• Cellular & Molecular Biology: Employed in patch-clamp electrophysiology and calcium imaging experiments to characterize ASIC channel properties and distribution.
• Ischemic Stroke Models: Applied in preclinical research to investigate the neuroprotective potential of ASIC1a inhibition following brain ischemia.
• Tool Compound Supply: Provided to biochemical suppliers and CROs (Contract Research Organizations) for inclusion in research kits and custom assay services.

Basic Information

Product Name	Phrixotoxin-1
CAS No.	221872-97-5
Molecular Formula	C152H246N48O44S6
Molecular Weight	~3510.3 g/mol
Synonyms	Phrixotoxin 1; PrTx1; ASIC1a inhibitor peptide; Acid-sensing ion channel 1a blocker; μ-Theraphotoxin-Pc1a; PcTx1 (Note: PcTx1 is a closely related but distinct spider toxin; Phrixotoxin-1 is often used synonymously in early literature but refers to a specific variant); Psalmotoxin-1 analog; ASIC channel inhibitor
EINECS	Contact for details

Quality Control

Our Phrixotoxin-1 is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to rigorous quality testing protocols, and specifications can be aligned with research-grade standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity (IC50)	Reported value provided per batch
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.