Description

Boc-5-Fluoro-2-Methylaniline is a high-purity, protected aniline derivative, specifically an N-Boc (tert-butoxycarbonyl) protected amine, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a versatile and stable amine precursor that is essential for constructing complex molecules, particularly in pharmaceutical research and development. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Peptide Mimetic Synthesis: Used in the construction of non-natural amino acids and peptide analogs where the protected amine group is crucial for selective coupling reactions.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides that incorporate fluorinated aniline motifs.
• Material Science: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials that require specific aromatic amine functionalities.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex aromatic amines.
• Protecting Group Strategy: The Boc group allows for orthogonal protection/deprotection sequences in multi-step synthetic routes, enabling greater synthetic flexibility.

Basic Information

Product Name	Boc-5-Fluoro-2-Methylaniline
CAS No.	221537-99-1
Molecular Formula	C₁₂H₁₆FNO₂
Molecular Weight	225.26 g/mol
Synonyms	1,1-Dimethylethyl N-(5-fluoro-2-methylphenyl)carbamate; tert-Butyl (5-fluoro-2-methylphenyl)carbamate; N-Boc-5-fluoro-2-methylaniline; N-(tert-Butoxycarbonyl)-5-fluoro-2-methylaniline; 5-Fluoro-2-methylaniline N-Boc derivative; Boc-5-Fluoro-o-toluidine; (5-Fluoro-2-methylphenyl)carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Boc-5-Fluoro-2-Methylaniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including process development and cGMP needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.