Description

Fmoc-n-Me-Abu(4)-Oh CAS NO 221124-57-8 is a protected amino acid derivative, specifically an Fmoc-protected, N-methylated variant of 2-aminobutyric acid. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of N-methylated residues to enhance peptide stability, bioavailability, and biological activity. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of novel therapeutic peptides, peptidomimetics, and proteomics research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the automated synthesis of complex peptides containing N-methyl amino acids.
• Pharmaceutical Research & Development: For constructing peptide-based drug candidates with improved metabolic stability and membrane permeability.
• Peptidomimetic Design: Serving as a scaffold to create molecules that mimic natural peptides but with enhanced pharmacological properties.
• Chemical Biology & Proteomics: Used in the synthesis of labeled peptides and activity-based probes for studying enzyme function and protein-protein interactions.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of peptide-like compounds for high-throughput screening.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic chemistry and peptide science.

Basic Information

Product Name	Fmoc-n-Me-Abu(4)-Oh
CAS No.	221124-57-8
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-N-methyl-2-aminobutyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-2-aminobutyric acid; Fmoc-N-Me-Abu-OH; Fmoc-N-methyl-Abu-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]butanoic acid; N-Fmoc-N-methyl-2-aminobutanoic acid; Fmoc-N-Me-2-Abu-OH
EINECS	Contact for details

Quality Control

Our Fmoc-n-Me-Abu(4)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.