Description

3',5'-Difluorobiphenyl-4-Carbaldehyde is a high-purity fluorinated biphenyl derivative, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in its precise molecular architecture, which enables the construction of complex molecules for high-performance applications. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluorobiphenyl moiety can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a foundational unit in the synthesis of fluorinated liquid crystal compounds and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Ligand & Catalyst Development: Employed in the design and synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Polymer & Resin Modifier: Acts as a monomer or cross-linking agent to introduce fluorine atoms into polymer backbones, enhancing chemical resistance and thermal stability.
• Academic & Industrial R&D: A valuable reagent for methodological studies in cross-coupling reactions and fluorination chemistry within research laboratories.

Basic Information

Product Name	3',5'-Difluorobiphenyl-4-Carbaldehyde
CAS No.	221018-03-7
Molecular Formula	C13H8F2O
Molecular Weight	218.20 g/mol
Synonyms	4-(3,5-Difluorophenyl)benzaldehyde; (3,5-Difluorophenyl)benzaldehyde-4-carboxaldehyde; 4-Formyl-3',5'-difluorobiphenyl; Biphenyl-4-carboxaldehyde, 3',5'-difluoro-; 3,5-Difluoro-4'-formylbiphenyl; 4-(3,5-Difluorophenyl)benzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3',5'-Difluorobiphenyl-4-Carbaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis via HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.