Description

4-Bromo-2-(trifluoromethoxy)benzaldehyde is a versatile and high-value aromatic aldehyde building block, distinguished by its bromine and trifluoromethoxy substituents. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling the synthesis of advanced materials and pharmaceuticals. It is primarily sought after by research chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for constructing complex heterocycles and active intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor for advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts due to its unique electronic profile.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where halogen and fluorine substituents tune electronic properties.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic and R&D Laboratories: Utilized in methodological development and exploratory chemistry research involving cross-coupling and functional group transformations.

Basic Information

Product Name	4-Bromo-2-(trifluoromethoxy)benzaldehyde
CAS No.	220996-80-5
Molecular Formula	C8H4BrF3O2
Molecular Weight	269.02 g/mol
Synonyms	4-Bromo-2-(trifluoromethoxy)benzaldehyde; 2-Trifluoromethoxy-4-bromobenzaldehyde; 4-Bromo-α,α,α-trifluoro-o-anisaldehyde; Benzaldehyde, 4-bromo-2-(trifluoromethoxy)-; 220996-80-5; 4-Bromo-2-trifluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(trifluoromethoxy)benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.