Description

Fmoc-L-His-Oall CAS NO 220932-33-2 is a protected derivative of the essential amino acid L-Histidine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise, high-yield incorporation of histidine residues while preventing unwanted side reactions during peptide chain assembly. It is an indispensable building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the automated synthesis of complex peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based therapeutics, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for targeted delivery systems.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic & Institutional Research: Essential for biochemical studies investigating protein-protein interactions, enzyme mechanisms, and structural biology.
• API Intermediate Manufacturing: Acts as a critical raw material in the cGMP production of active pharmaceutical ingredients (APIs) for peptide drugs.

Basic Information

Product Name	Fmoc-L-His-Oall
CAS No.	220932-33-2
Molecular Formula	C25H25N3O5
Molecular Weight	447.49 g/mol
Synonyms	Fmoc-L-histidine-O-allyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-histidine allyl ester; Fmoc-His-OAll; Fmoc-His(OAll)-OH; Allyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-histidinate; Nα-Fmoc-Nim-alloc-L-histidine; Fmoc-His(Alloc)-OH (common misnomer, refers to side-chain protection); L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, allyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-L-His-Oall is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.