Description

Fmoc-Ya-Oh CAS NO 220886-40-8 is a high-purity, protected amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over side-chain functionality during solid-phase peptide assembly. It is an essential building block for pharmaceutical R&D, particularly in the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the sequential construction of complex peptide chains, especially where tyrosine side-chain protection is required.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic, oncological, and neurological disorders.
• Research & Development: Used in academic and industrial laboratories for exploring new peptide sequences, structure-activity relationships (SAR), and novel bioconjugation strategies.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Bioconjugation & Probe Development: The reactive carboxylic acid group allows for coupling to other molecules, useful in creating fluorescent probes, affinity tags, or peptide-drug conjugates.
• Custom Peptide Service: A fundamental reagent for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide synthesis services.

Basic Information

Item	Detail
Product Name	Fmoc-Ya-Oh
CAS No.	220886-40-8
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-Tyr(Alloc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[(2-propen-1-yloxy)carbonyl]-L-tyrosine; Fmoc-L-Tyrosine(Alloc)-OH; Fmoc-O-alloc-L-tyrosine; N-α-Fmoc-O-alloc-L-tyrosine; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-(prop-2-enoxycarbonyloxy)phenyl]propanoic acid; Fmoc-Tyr(Alloc)-OH (L-form); Fmoc-L-Tyr(Alloc)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Ya-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1, DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.