Description

4-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is a high-value fluorinated pyrimidine derivative, a crucial building block in modern synthetic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in oncology, antiviral, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a specialized monomer or ligand in the synthesis of advanced materials, including liquid crystals and organic semiconductors.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes, enzyme inhibitors, and other tools for biochemical research.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services and fine chemical production under cGMP or ISO standards.

Basic Information

Product Name	4-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid
CAS No.	220880-12-6
Molecular Formula	C6H3F3N2O2
Molecular Weight	192.10 g/mol
Synonyms	5-Pyrimidinecarboxylic acid, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-5-pyrimidinecarboxylic acid; 4-Trifluoromethylpyrimidine-5-carboxylic acid; 4-(Trifluoromethyl)pyrimidine-5-carboxylic acid; 220880-12-6; 4-Trifluoromethyl-5-pyrimidinecarboxylic acid; 4-(Trifluoromethyl)-5-carboxypyrimidine
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with full traceability are provided with every shipment. We support development and commercial projects with material suitable for research use, pilot plant, and cGMP manufacturing, with specifications tailored to your project phase.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.