Description

Ng,Ng-Dimethyl-L-Arginine Dihydrochloride is a high-purity, chemically modified derivative of the essential amino acid L-Arginine. This compound is critical for biochemical research and pharmaceutical development, particularly in the study of nitric oxide synthase (NOS) inhibition and cellular signaling pathways. It serves as a key intermediate and reference standard for scientists in the life sciences, pharmaceutical, and biotechnology industries.

Application

• Biochemical Research: Used as a potent and selective inhibitor of nitric oxide synthase (NOS) isoforms in enzymatic and cellular studies.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of novel therapeutic agents targeting cardiovascular and neurological disorders.
• Reference Standard: Employed as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolic Pathway Studies: A vital tool for investigating the role of methylated arginine derivatives in cellular metabolism and disease states.
• Proteomics & Cell Biology: Used in studies of protein arginine methylation, a key post-translational modification regulating gene expression and signal transduction.

Basic Information

Product Name	Ng,Ng-Dimethyl-L-Arginine Dihydrochloride
CAS No.	220805-22-1
Molecular Formula	C8H20N4O2 · 2HCl
Molecular Weight	285.19 g/mol
Synonyms	Asymmetric Dimethylarginine Dihydrochloride; ADMA·2HCl; NG,NG-Dimethylarginine Dihydrochloride; L-NG,NG-Dimethylarginine Dihydrochloride; (S)-2-Amino-5-[(amino-dimethylaminomethylene)amino]pentanoic acid dihydrochloride; N(G),N(G)-Dimethyl-L-arginine dihydrochloride; H-Arg(Me2)-OH·2HCl
EINECS	Contact for details

Quality Control

Our Ng,Ng-Dimethyl-L-Arginine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: +20.0° to +26.0° (c=1 in H2O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.