Description

Antisauvagine-30 is a potent and selective peptide antagonist of the corticotropin-releasing factor type 2 (CRF₂) receptor. This compound is a critical research tool for neuropharmacological studies, enabling the specific investigation of CRF₂ receptor-mediated pathways and their physiological roles. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies engaged in stress-related disorder research, anxiety studies, and central nervous system drug discovery.

Application

• Neuropharmacological Research: A key tool for studying the specific functions of the CRF₂ receptor subtype in the brain and peripheral nervous system.
• Stress Response Studies: Used in preclinical models to dissect the role of CRF₂ receptors in behavioral, endocrine, and autonomic responses to stress.
• Anxiety and Depression Research: Facilitates the investigation of CRF₂ pathways in mood and anxiety disorders to identify novel therapeutic targets.
• Cardiovascular Research: Employed to explore the influence of CRF₂ receptors on heart rate, blood pressure, and vascular function.
• Gastrointestinal Function Studies: Applied in research on CRF₂ receptor involvement in gut motility, visceral pain, and stress-related GI disorders.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening and lead optimization for CNS therapeutics.

Basic Information

Product Name	Antisauvagine-30
CAS No.	220673-95-0
Molecular Formula	C₁₄₈H₂₄₈N₅₀O₄₅
Molecular Weight	~3439.9 g/mol
Synonyms	Antisauvagine-30; Cyclo(30-33)[Ac-Pro⁷⁰,D-Phe¹¹,His¹²,Nle¹⁷,³⁸,Glu³⁰,Lys³³]Svg(30-33) amide; CRF₂ Receptor Antagonist; Sauvagine (30-33) amide, cyclo(30-33)[Ac-Pro⁷⁰,D-Phe¹¹,His¹²,Nle¹⁷,³⁸,Glu³⁰,Lys³³]-; Astressin 2B; [Ac-Pro⁷⁰,D-Phe¹¹,His¹²,Nle¹⁷,³⁸,Glu³⁰,Lys³³]Svg(30-33) amide
EINECS	Contact for details

Quality Control

Our Antisauvagine-30 is manufactured under strict quality-controlled conditions to ensure high purity and batch-to-batch consistency for research applications. Each lot is characterized using advanced analytical techniques, including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Peptide Content	≥80%
Water Content (KF)	≤5.0%
Acetate Content (HPLC)	≤10.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.