Description

Fmoc-(R)-3-Amino-3-(4-Bromo-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a brominated aromatic side chain. This compound is critically important as a key chiral building block in the solid-phase synthesis of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D and biotechnology organizations for developing novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid for the automated synthesis of peptide sequences containing bromophenylalanine analogs.
• Pharmaceutical Intermediate: A crucial chiral precursor in the research and development of new active pharmaceutical ingredients (APIs) and drug candidates.
• Peptidomimetic Design: Used to incorporate a rigid, hydrophobic, and halogenated aromatic moiety into peptide backbones to enhance binding affinity and metabolic stability.
• Chemical Biology Probes: Synthesis of labeled peptides or affinity tags for studying protein-protein interactions and biological pathways.
• Combinatorial Chemistry: A valuable building block for creating diverse chemical libraries for high-throughput screening in drug discovery.
• Academic & Contract Research: Fundamental research in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(4-Bromo-Phenyl)-Propionic Acid
CAS No.	220498-04-4
Molecular Formula	C24H20BrNO4
Molecular Weight	466.33 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(4-bromophenyl)propanoic Acid; (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-bromophenyl)propanoic Acid; Fmoc-(R)-4-Bromo-Phe(3)-OH; Fmoc-β-homo-4-bromo-(R)-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(4-bromophenyl)propionic Acid; Nα-Fmoc-3-amino-3-(4-bromophenyl)-(R)-propionic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-bromophenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(4-Bromo-Phenyl)-Propionic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, NMR, and optical rotation analysis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.