Description

Fmoc-(R)-3-Amino-3-Phenylpropionic Acid is a high-purity, enantiomerically pure amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of peptides and peptidomimetics containing unnatural amino acid residues. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Peptidomimetic Design: Incorporation of the (R)-3-amino-3-phenylpropionic acid scaffold to create novel drug candidates with enhanced stability and bioavailability.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: A valuable tool for probing enzyme mechanisms and studying protein-protein interactions.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify new lead compounds.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-Phenylpropionic Acid
CAS No.	220498-02-2
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	(R)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-phenylpropanoic Acid; Fmoc-D-β-Homophenylalanine; Fmoc-(R)-3-Amino-3-phenylpropanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-phenylpropionic Acid; (R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-phenylpropanoic Acid; Fmoc-β-homo-Phe-OH; N-Fmoc-3-amino-3-phenylpropionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-Phenylpropionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to industry best practices and can support requirements for cGMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.