Description

Fmoc-D-3-Thienylalanine CAS NO 220497-90-5 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected α-amino group and a thienyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of the D-enantiomer of 3-thienylalanine into complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and materials science applications where specific steric and electronic properties are required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: For the development of peptide-based drugs, hormone analogs, and diagnostic agents incorporating non-natural amino acids.
• Peptidomimetic Design: Used to create stable peptide analogs with enhanced bioavailability or altered receptor binding profiles.
• Chemical Biology Probes: Incorporation into peptides to study protein-protein interactions, enzyme mechanisms, and cellular signaling.
• Material Science: As a monomer for constructing bio-inspired polymers and functional surfaces with unique electronic properties from the thiophene moiety.
• Academic & Industrial R&D: For fundamental research in organic chemistry, medicinal chemistry, and biochemistry.

Basic Information

Product Name	Fmoc-D-3-Thienylalanine
CAS No.	220497-90-5
Molecular Formula	C22H19NO4S
Molecular Weight	393.45 g/mol
Synonyms	Fmoc-D-3-Thienylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-thienyl)-D-alanine; Fmoc-D-β-(3-Thienyl)-Ala-OH; Fmoc-D-3-Thienyl-Ala-OH; N-Fmoc-3-(3-thienyl)-D-alanine; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid; Fmoc-D-3-ThiaAla-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-3-Thienylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.