Description

Fmoc-L-2-Amino-4-Bromo-4-Pentenoic Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is a critical building block for introducing the unique 2-amino-4-bromo-4-pentenoic acid moiety, which enables the study of protein-protein interactions and the development of novel therapeutic agents. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic institutions focused on peptide-based drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing the bromoalkene functional group.
• Medicinal Chemistry & Drug Discovery: Used to incorporate a versatile handle for further chemical modification (e.g., cross-coupling, click chemistry) into peptide backbones for structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Serves as a precursor for creating activity-based probes or affinity labels to study enzyme function and protein interactions.
• Peptidomimetic Development: Enables the synthesis of peptide analogs with enhanced stability, bioavailability, or target specificity.
• Academic & Industrial Research: A fundamental reagent for exploring new synthetic methodologies and the biochemical properties of modified peptides.

Basic Information

Product Name	Fmoc-L-2-Amino-4-Bromo-4-Pentenoic Acid
CAS No.	220497-60-9
Molecular Formula	C₂₀H₁₈BrNO₄
Molecular Weight	416.27 g/mol
Synonyms	Fmoc-Abr(Br)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-amino-4-bromo-4-pentenoic acid; Fmoc-2-Amino-4-bromopent-4-enoic acid; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-4-bromopent-4-enoic acid; Fmoc-L-Abr(Br)-OH; Fmoc-L-2-Amino-4-bromopent-4-enoic Acid; Nα-Fmoc-L-2-amino-4-bromo-4-pentenoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-Amino-4-Bromo-4-Pentenoic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive research applications. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the product label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.