Description

(S)-n-Fmoc-(5-Bromo-2-Methoxyphenyl)Alanine is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the development of novel peptide-based therapeutics and biochemical tools, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of complex peptides, peptidomimetics, and PROTACs. Its unique bromo-methoxy phenyl side chain provides a versatile handle for further functionalization via cross-coupling reactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides with specific side-chain functionality.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of targeted peptide drugs and bioactive molecules.
• Peptidomimetic Design: Used to incorporate non-natural aromatic amino acid analogs into peptide backbones to enhance stability, bioavailability, and binding affinity.
• PROTAC (Proteolysis Targeting Chimera) Linker Construction: Employed in the synthesis of the peptide-based linker segment that connects the E3 ligase ligand to the target protein ligand.
• Chemical Biology Probes: Integral for creating labeled or tagged peptides used in studying protein-protein interactions and cellular pathways.
• Academic & Industrial Research: A valuable reagent for exploring new synthetic methodologies and structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Item	Detail
Product Name	(S)-n-Fmoc-(5-Bromo-2-Methoxyphenyl)Alanine
CAS No.	220497-51-8
Molecular Formula	C25H22BrNO5
Molecular Weight	496.35 g/mol
Synonyms	Fmoc-5-Br-2-OMe-Phe-OH; Fmoc-(5-Bromo-2-methoxy-DL-phenyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-bromo-2-methoxy-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(5-bromo-2-methoxyphenyl)propanoic acid; Fmoc-5-Bromo-2-methoxy-L-phenylalanine; Fmoc-L-5-Br-2-OMe-Phe-OH; N-α-Fmoc-5-bromo-2-methoxy-L-phenylalanine; L-Fmoc-5-Bromo-2-Methoxyphenylalanine
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-(5-Bromo-2-Methoxyphenyl)Alanine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.