Description

Fmoc-L-2-(5-Bromothienyl)Alanine CAS NO 220497-50-7 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis and medicinal chemistry research. This compound is a critical building block for the solid-phase synthesis of complex peptides, enabling the incorporation of a unique bromothiophene side chain that can be leveraged for further functionalization via cross-coupling reactions. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical discovery, and materials science who require precise molecular tools to create novel bioactive compounds and functional polymers.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of custom peptides containing the 5-bromothienylalanine moiety.
• Pharmaceutical R&D: Used in the discovery and development of novel drug candidates, particularly for creating peptide-based therapeutics, protease inhibitors, and targeted biologics.
• Chemical Biology Probes: Enables the site-specific introduction of a handle (bromine) for bioconjugation, labeling, or further derivatization in probe and tool compound development.
• Agrochemical Research: Serves as a building block for synthesizing peptide-mimetic active ingredients and growth regulators.
• Materials Science: Incorporation into specialty polymers and smart materials to impart specific electronic or self-assembly properties derived from the thiophene unit.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to identify new lead compounds with optimized properties.

Basic Information

Product Name	Fmoc-L-2-(5-Bromothienyl)Alanine
CAS No.	220497-50-7
Molecular Formula	C22H18BrNO4S
Molecular Weight	472.35 g/mol
Synonyms	Fmoc-5-BrT(2)Ala-OH; Fmoc-L-β-(5-Bromo-2-thienyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-bromo-2-thienylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-(5-bromothiophen-2-yl)propanoic acid; Fmoc-5-Bromo-2-thienyl-L-alanine; Fmoc-L-2-(5-Bromo-2-thienyl)alanine; Fmoc-β-(5-Bromo-2-thienyl)-L-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-2-(5-Bromothienyl)Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.