Description

(S,S)-Methohexital is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is critical for research and development in the field of anesthesiology and neuropharmacology, serving as a key building block for specialized barbiturate derivatives. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the synthesis of active pharmaceutical ingredients (APIs) and pharmacological studies.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of advanced anesthetic and sedative agents.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating the mechanism of action of barbiturates on GABAA receptors.
• Process Development: Serves as a critical material for optimizing and scaling up synthetic routes in API manufacturing.
• Metabolite Studies: Used in the identification and characterization of drug metabolites in pharmacokinetic research.

Basic Information

Product Name	(S,S)-Methohexital
CAS No.	220465-06-5
Molecular Formula	C14H18N2O3
Molecular Weight	262.30 g/mol
Synonyms	(S,S)-Methohexital; (5S,6S)-1-Methyl-5-(1-methyl-2-pentyn-1-yl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyrimidinetrione; (S,S)-Methohexitone; (S,S)-Brevital; Enantiomer of Methohexital; (5S,6S)-Methohexital; (S,S)-Methohexital Sodium; (S,S)-Methohexital free acid
EINECS	Contact for details

Quality Control

Our (S,S)-Methohexital is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S,S)-enantiomer
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.