Description

(3Ar,4S,6R,6As)-6-[7-Chloro-5-(Propylthio)-3H-1,2,3-Triazolo[4,5-D]Pyrimidin-3-Yl]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol is a high-purity, complex heterocyclic compound featuring a fused triazolopyrimidine core, a key structural motif in advanced pharmaceutical research. This molecule is valued for its role as a sophisticated chemical intermediate or reference standard in the development of novel active pharmaceutical ingredients (APIs). It is primarily targeted at pharmaceutical R&D laboratories and fine chemical manufacturers engaged in cutting-edge drug discovery programs, particularly those exploring nucleoside analogs or enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of potential drug candidates, especially those targeting viral or oncological pathways.
• Research & Development: Used as a high-purity reference standard in analytical method development, process chemistry optimization, and structure-activity relationship (SAR) studies.
• Biochemical Probe: Potential utility as a tool compound for investigating biological mechanisms involving purine or pyrimidine recognition sites.
• Academic Research: Employed in university and institutional labs for synthetic organic chemistry projects and the exploration of new heterocyclic chemistry.
• Process Development: Acts as a key material for scaling up synthetic routes from milligram to kilogram scale under current Good Manufacturing Practice (cGMP) conditions.
• Custom Synthesis: A starting point for the preparation of more complex, proprietary derivatives for client-specific drug discovery collaborations.

Basic Information

Item	Detail
Product Name	(3Ar,4S,6R,6As)-6-[7-Chloro-5-(Propylthio)-3H-1,2,3-Triazolo[4,5-D]Pyrimidin-3-Yl]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol
CAS No.	220241-61-2
Molecular Formula	C17H22ClN5O3S
Molecular Weight	411.91 g/mol
Synonyms	7-Chloro-5-(propylthio)-3-((3aR,4S,6R,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; (3aR,4S,6R,6aR)-6-[7-Chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol; 220241-61-2; Triazolopyrimidine derivative; Cyclopentadioxolyl triazolopyrimidine.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and controlled under a strict quality management system. We provide comprehensive analytical data to support your research and regulatory filings. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment. Our standard quality commitment includes compliance with relevant ICH guidelines for impurities and stability, ensuring the material is suitable for use in pre-clinical and early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the certificate of analysis. The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.