Description

(3Ar,4S,6R,6As)-6-[[5-Amino-6-Chloro-2-(Propylthio)-4-Pyrimidinyl]Amino]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol is a sophisticated chiral intermediate of significant importance in modern pharmaceutical synthesis. Its complex stereochemistry and functional groups make it a critical building block for the development of high-value, optically active active pharmaceutical ingredients (APIs). This compound is essential for research and manufacturing organizations focused on nucleoside analog therapeutics and antiviral agents, where precise molecular configuration is paramount for efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel nucleoside analog antiviral drugs.
• Antiviral Drug Development: Used in research and production of potential therapeutics targeting specific viral polymerases.
• Organic Synthesis: Serves as a versatile building block for constructing complex heterocyclic systems with defined stereocenters.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for target molecules in clinical development.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.
• Contract Manufacturing (CMO): Supplied to CMOs specializing in the production of advanced pharmaceutical intermediates under cGMP.

Basic Information

Item	Detail
Product Name	(3Ar,4S,6R,6As)-6-[[5-Amino-6-Chloro-2-(Propylthio)-4-Pyrimidinyl]Amino]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol
CAS No.	220241-60-1
Molecular Formula	C16H25ClN4O3S
Molecular Weight	388.91 g/mol
Synonyms	6-[(5-Amino-6-chloro-2-propylsulfanylpyrimidin-4-yl)amino]-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol; (3aR,4S,6R,6aS)-6-[(5-Amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino]tetrahydro-2,2-dimethyl-4H-cyclopenta[d][1,3]dioxol-4-ol; 2,2-Dimethyl-4H-cyclopenta-1,3-dioxol-4-ol, 6-[(5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl)amino]tetrahydro-, (3aR,4S,6R,6aS)-; A Chiral Cyclopentane-Fused Dioxolane Pyrimidine Intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our facility operates under ISO 9001 standards, and we can support development projects requiring cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.