Description

(3Ar,4S,6R,6As)-6-[[6-Chloro-5-Nitro-2-(Propylthio)-4-Pyrimidinyl]Amino]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its complex stereochemistry and functionalized pyrimidine core. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in antiviral and oncology research. It is essential for process development chemists and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of nucleoside analog antiviral drugs and targeted cancer therapies.
• Antiviral Drug Development: Used in research and production of compounds targeting viral polymerases and reverse transcriptases.
• Oncology Research: Serves as a precursor for small molecule inhibitors and other therapeutic agents in preclinical and clinical development.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and kilogram-to-ton scale manufacturing of complex APIs.
• Custom Synthesis: A starting material for the preparation of specialized derivatives and analogs for structure-activity relationship (SAR) studies.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production.

Basic Information

Product Name	(3Ar,4S,6R,6As)-6-[[6-Chloro-5-Nitro-2-(Propylthio)-4-Pyrimidinyl]Amino]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Ol
CAS No.	220241-59-8
Molecular Formula	C17H23ClN4O5S
Molecular Weight	430.91 g/mol
Synonyms	6-[(6-Chloro-5-nitro-2-propylsulfanylpyrimidin-4-yl)amino]-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol; (3aR,4S,6R,6aS)-6-[(6-Chloro-5-nitro-2-propylsulfanylpyrimidin-4-yl)amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol; 6-[[6-Chloro-5-nitro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol; CAS 220241-59-8; Advanced Pyrimidine Intermediate; Chiral Cyclopentadioxolane Derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and isomeric purity suitable for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development under cGMP guidelines for projects requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.