Description

4-Fluoro-2-(Trifluoromethyl)Benzyl Alcohol is a versatile fluorinated aromatic building block of significant interest in advanced chemical synthesis. This compound matters for its unique molecular structure, which combines fluorine and trifluoromethyl groups to impart desirable properties like metabolic stability and lipophilicity to target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine motifs enhance biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronics: Employed in the development of novel materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: Acts as a valuable substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Protecting Group Chemistry: The benzyl alcohol functionality can be used in protective group strategies during multi-step synthetic routes.

Basic Information

Product Name	4-Fluoro-2-(Trifluoromethyl)Benzyl Alcohol
CAS No.	220227-29-2
Molecular Formula	C8H6F4O
Molecular Weight	194.13 g/mol
Synonyms	(4-Fluoro-2-(trifluoromethyl)phenyl)methanol; α,α,α-Trifluoro-4-fluoro-o-tolylcarbinol; 2-(Trifluoromethyl)-4-fluorobenzyl alcohol; 4-Fluoro-α,α,α-trifluoro-o-tolyl alcohol; 4-Fluoro-2-trifluoromethylbenzenemethanol; 1-(Hydroxymethyl)-4-fluoro-2-(trifluoromethyl)benzene; 4-Fluoro-α,α,α-trifluoro-2-methylbenzenemethanol
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-(Trifluoromethyl)Benzyl Alcohol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.