Description

3',4',5'-Trifluoroacetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of three fluorine atoms on the aromatic ring, which profoundly influences the electronic and steric properties of downstream molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it serves as a key intermediate for developing novel active ingredients, including kinase inhibitors and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging fluorine's ability to enhance bioavailability and metabolic stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique optical and electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, Friedel-Crafts acylations, and as a precursor for heterocyclic compounds in academic and industrial R&D.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) and the effects of polyfluorination on molecular behavior.

Basic Information

Product Name	3',4',5'-Trifluoroacetophenone
CAS No.	220141-73-1
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	1-(3,4,5-Trifluorophenyl)ethanone; 3,4,5-Trifluoroacetophenone; 3,4,5-Trifluorophenyl methyl ketone; Ethanone, 1-(3,4,5-trifluorophenyl)-; 3,4,5-Trifluoroacetylbenzene; 3,4,5-Trifluorobenzoyl methane; 3,4,5-Trifluoro phenylacetone
EINECS	Contact for details

Quality Control

Our 3',4',5'-Trifluoroacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency, suitable for demanding research and production applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.