Description

3,4,5-Trifluorobenzyl Bromide CAS NO 220141-72-0 is a high-purity fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the introduction of a reactive benzylic bromide group adjacent to a highly fluorinated aromatic ring, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require sophisticated intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for CNS and oncology targets.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides where the trifluoromethylphenyl moiety enhances bioavailability and stability.
• Liquid Crystal & OLED Materials: Used in the production of fluorinated components for electronic display and lighting technologies.
• Cross-Coupling Reactions: Essential reagent in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized phosphine and N-heterocyclic carbene (NHC) ligands.
• Polymer Modification: Incorporates fluorinated aromatic units into polymer backbones to alter thermal, chemical, and surface properties.

Basic Information

Product Name	3,4,5-Trifluorobenzyl Bromide
CAS No.	220141-72-0
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	(3,4,5-Trifluorophenyl)methyl Bromide; α-Bromo-3,4,5-trifluorotoluene; 3,4,5-Trifluoro-α-bromotoluene; 1-(Bromomethyl)-3,4,5-trifluorobenzene; Benzene, 1-(bromomethyl)-3,4,5-trifluoro-; 3,4,5-Trifluorobenzylbromide
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorobenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.