Description

tert-Butyl 2-chloropyrimidine-4-carboxylate is a high-purity, versatile pyrimidine building block essential for advanced organic synthesis. Its value lies in the reactive chloropyrimidine core and the acid-labile tert-butyl ester protecting group, enabling precise molecular construction. This compound is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of kinase inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Chemical Biology: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways.
• Material Science Research: Employed in the synthesis of functionalized heterocyclic compounds for advanced materials.
• Cross-Coupling Reactions: The chlorine atom is amenable to palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for diversification.
• Ester Deprotection Studies: The tert-butyl ester group can be selectively cleaved under acidic conditions, making it useful in multi-step synthetic sequences.

Basic Information

Product Name	tert-Butyl 2-Chloropyrimidine-4-Carboxylate
CAS No.	220041-42-9
Molecular Formula	C9H11ClN2O2
Molecular Weight	214.65 g/mol
Synonyms	2-Chloropyrimidine-4-carboxylic acid tert-butyl ester; tert-Butyl 2-chloro-4-pyrimidinecarboxylate; 4-Pyrimidinecarboxylic acid, 2-chloro-, 1,1-dimethylethyl ester; 2-Chloro-4-(tert-butoxycarbonyl)pyrimidine; 2-Chloro-4-pyrimidinecarboxylic acid tert-butyl ester; 2-Chloro-4-(tert-butoxycarbonyl)pyrimidine; 4-(tert-Butoxycarbonyl)-2-chloropyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-chloropyrimidine-4-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to guarantee consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.