Description

4-Fmoc-Piperazine-2-Carboxylic Acid is a high-purity, protected amino acid derivative essential for modern peptide synthesis. Its core value lies in providing a versatile, orthogonally protected piperazine building block, enabling the precise construction of complex molecular architectures. This compound is critically needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel active pharmaceutical ingredients (APIs), peptide-based therapeutics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled incorporation of constrained piperazine scaffolds into peptide chains.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of drug candidates, particularly for central nervous system (CNS) targets, oncology, and GPCR modulators.
• Combinatorial Chemistry: Used in the generation of diverse chemical libraries for high-throughput screening and drug discovery programs.
• Conformationally Constrained Peptide Mimetics: Enables the synthesis of peptides with restricted flexibility to enhance binding affinity, metabolic stability, and selectivity.
• Chemical Biology Research: Employed in the synthesis of labeled peptides, affinity tags, and molecular tools for studying biological processes.
• Process Development & Scale-Up: Supports the transition from laboratory-scale research to commercial manufacturing of peptide-based pharmaceuticals.

Basic Information

Product Name	4-Fmoc-Piperazine-2-Carboxylic Acid
CAS No.	219312-90-0
Molecular Formula	C₂₁H₂₂N₂O₄
Molecular Weight	366.41 g/mol
Synonyms	Fmoc-Pip(2-COOH)-OH; 2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,4-diazabicyclo[4.4.0]decane-3-carboxylic acid; 1-Fmoc-piperazine-2-carboxylic acid; 4-[(9-Fluorenylmethoxycarbonyl)]-2-piperazinecarboxylic acid; N-α-Fmoc-piperazine-2-carboxylic acid; (2S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid; (2R)-4-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid; Fmoc-Pip-OH
EINECS	Contact for details

Quality Control

Our 4-Fmoc-Piperazine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.