Description

L-β-Homoisoleucine Hydrochloride is a high-purity, non-proteinogenic amino acid derivative, specifically the hydrochloride salt of the L-β-homo form of isoleucine. This compound is of significant value in advanced pharmaceutical research and development, particularly in the synthesis of novel peptides and peptidomimetics where structural modification is required to enhance metabolic stability or receptor binding affinity. It serves as a critical chiral building block for medicinal chemists and researchers in the life sciences sector, enabling the exploration of new therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and neurological disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified amino acid structures, potentially improving peptide stability and bioavailability.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate amino acid metabolism and transport mechanisms.
• Proteomics & Molecular Biology: Useful in the design and synthesis of custom peptides for antibody production, protein labeling, and structure-activity relationship (SAR) studies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and analytical laboratories.

Basic Information

Product Name	L-β-Homoisoleucine Hydrochloride
CAS No.	219310-10-8
Molecular Formula	C7H15NO2 · HCl
Molecular Weight	197.66 g/mol (Free base: 145.20)
Synonyms	(2S)-2-Amino-4-methylhexanoic acid hydrochloride; L-β-Homoisoleucine HCl; (S)-2-Amino-4-methylhexanoic acid hydrochloride; β-Homo-L-isoleucine hydrochloride; L-2-Amino-4-methylhexanoic acid hydrochloride; H-Ile(β-homo)-OH · HCl; 4-Methyl-DL-norleucine hydrochloride (related); Amino acid derivative C7 HCl
EINECS	Contact for details

Quality Control

Our L-β-Homoisoleucine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (typically ≥98% by HPLC), and specific tests for related substances, residual solvents, and heavy metals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.