Description

Boc-(S)-3-Amino-4-(1-Naphthyl)-Butyric Acid CAS NO 219297-09-3 is a high-purity, non-natural amino acid derivative featuring a chiral center and a bulky naphthyl side chain, protected by a tert-butoxycarbonyl (Boc) group. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, enabling the introduction of unique steric and hydrophobic properties into molecular structures. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in drug discovery, particularly for developing protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for metabolic and neurological disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a constrained, hydrophobic amino acid residue into peptide chains.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for enzymes like renin, HIV protease, and thrombin.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and labeled peptides for studying enzyme function and protein-protein interactions.
• Academic & Institutional Research: Used in university and government labs for fundamental research in medicinal chemistry and asymmetric synthesis.
• Custom Synthesis Services: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides and complex organic molecules for clients.

Basic Information

Product Name	Boc-(S)-3-Amino-4-(1-Naphthyl)-Butyric Acid
CAS No.	219297-09-3
Molecular Formula	C19H23NO4
Molecular Weight	329.39 g/mol
Synonyms	(S)-3-((tert-Butoxycarbonyl)amino)-4-(naphthalen-1-yl)butanoic acid; Boc-3-Amino-4-(1-naphthyl)butyric acid; (S)-Boc-3-Amino-4-(1-naphthyl)butanoic Acid; tert-Butyl (S)-(1-carboxy-3-(naphthalen-1-yl)propyl)carbamate; N-Boc-L-3-Amino-4-(1-naphthyl)butyric Acid; N-α-Boc-3-Amino-4-(1-naphthyl)butyric Acid; Boc-Abn-OH (Abn = 3-Amino-4-(1-naphthyl)butyric acid); 219297-09-3
EINECS	Contact for details

Quality Control

Our Boc-(S)-3-Amino-4-(1-Naphthyl)-Butyric Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral HPLC for enantiomeric excess, and spectroscopic methods (NMR, IR, MS) for structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development. Specifications are designed to meet the stringent requirements of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.