Description

Jagged-1 (188-204) is a synthetic peptide fragment corresponding to a specific region of the Jagged-1 protein, a critical ligand in the Notch signaling pathway. This high-purity biochemical is essential for researchers and developers studying cell fate determination, differentiation, and tissue development. It is primarily utilized in life science research, pharmaceutical R&D, and as a key reagent in the development of targeted therapeutic strategies.

Application

• Notch Signaling Pathway Research: Used as a specific activator to study the role of Jagged-1 mediated Notch signaling in cellular processes.
• Cell Culture & Differentiation Studies: Applied in stem cell and progenitor cell cultures to influence differentiation pathways and model developmental biology.
• Biochemical Assay Development: Serves as a standard or key component in ELISA, binding assays, and other in vitro diagnostic tests targeting the Notch pathway.
• Drug Discovery & Screening: Utilized in high-throughput screening platforms to identify and validate novel inhibitors or modulators of the Jagged-1/Notch interaction.
• Angiogenesis & Cancer Research: Investigated in models of tumor angiogenesis, metastasis, and cancer stem cell biology where Notch signaling is dysregulated.
• Reagent for Antibody Production: Acts as an immunogen or antigen for the generation and characterization of specific anti-Jagged-1 antibodies.

Basic Information

Item	Details
Product Name	Jagged-1 (188-204)
CAS No.	219127-21-6
Molecular Formula	C91H146N28O27S
Molecular Weight	2072.4 g/mol
Synonyms	Jagged-1 Peptide (188-204); Delta/Serrate/LAG-2 (DSL) domain peptide; hJagged1 (188-204); Recombinant Human Jagged-1 Peptide Fragment; CD339 peptide fragment; JAG1 (188-204); Notch ligand peptide; Synthetic Jagged-1 DSL peptide
EINECS	Contact for details

Quality Control

Every batch of Jagged-1 (188-204) is manufactured and tested under stringent quality management systems to ensure the highest standards of purity and batch-to-batch consistency. Our products undergo rigorous analytical testing, including reversed-phase HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with each shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider storing desiccated.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Retention time and mass conform to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Amino Acid Sequence	Cys-Ser-Pro-Pro-His-Ser-Gly-Gly-Gly-Val-Phe-Gln-Gln-Asp-Asp-Glu-Glu-Glu
Single Peptide Content (HPLC)	Main peak ≥ 90% of total area
Water Content (K.F.)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.