Description

[2-(3,4-Difluorophenyl)-2-Hydroxyethyl]-Carbamic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and cardiovascular disorders. It is essential for research and development chemists and manufacturing units in the global pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis pathways.

Application

• Key Intermediate in API Synthesis: Primarily used in the multi-step synthesis of novel pharmaceutical compounds, especially those containing a difluorophenyl pharmacophore.
• Neurological & Psychiatric Drug Development: A crucial precursor in the research and production of potential therapeutics for conditions such as depression, anxiety, and neurodegenerative diseases.
• Cardiovascular Drug Manufacturing: Employed in the synthesis pathway for APIs targeting hypertension and other cardiovascular conditions.
• Process Chemistry & Scale-Up: Used in process research, optimization, and pilot-to-commercial scale production of target molecules.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.
• Academic & Industrial R&D: Serves as a valuable reagent for medicinal chemistry programs and exploratory research in academic and corporate laboratories.

Basic Information

Product Name	[2-(3,4-Difluorophenyl)-2-Hydroxyethyl]-Carbamic Acid 1,1-Dimethylethyl Ester
CAS No.	218449-63-9
Molecular Formula	C13H17F2NO3
Molecular Weight	273.28 g/mol
Synonyms	tert-Butyl N-[2-(3,4-difluorophenyl)-2-hydroxyethyl]carbamate; N-Boc-2-amino-1-(3,4-difluorophenyl)ethanol; 1-(3,4-Difluorophenyl)-2-[(tert-butoxycarbonyl)amino]ethanol; 2-Amino-1-(3,4-difluorophenyl)ethanol N-Boc derivative; Boc-3,4-difluorophenylethanolamine; BOC-Difluorophenyl ethanolamine; (R/S)-N-Boc-1-(3,4-difluorophenyl)-2-aminoethanol; Carbamic acid, N-[2-(3,4-difluorophenyl)-2-hydroxyethyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our [2-(3,4-Difluorophenyl)-2-Hydroxyethyl]-Carbamic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.