Description

(Biotinyl-Gln1)-Lhrh CAS NO 218433-98-8 is a biotinylated derivative of the Gonadotropin-Releasing Hormone (GnRH) decapeptide, designed for advanced research and diagnostic applications. This modified peptide is critical for studying receptor-ligand interactions with high sensitivity and specificity, leveraging the strong affinity of biotin for streptavidin. It is primarily utilized by research institutions and diagnostic manufacturers in the fields of endocrinology, oncology, and reproductive biology for assay development, biomarker detection, and targeted drug delivery research.

Application

• Bioconjugation & Assay Development: Serves as a key reagent for developing sensitive ELISA, Western blot, and other immunoassays by providing a stable biotin tag for streptavidin-based detection systems.
• Targeted Cancer Research: Used in preclinical studies to investigate GnRH receptor-targeted therapies and imaging agents for cancers expressing these receptors, such as prostate, breast, and ovarian cancers.
• Reproductive Endocrinology Studies: Facilitates fundamental research into the hypothalamic-pituitary-gonadal axis, hormone regulation, and the development of novel fertility treatments.
• Diagnostic Kit Manufacturing: Incorporated as a critical component in the production of in-vitro diagnostic (IVD) kits for hormone level measurement and related pathological conditions.
• Affinity Purification & Pull-Down Assays: Enables the isolation and study of GnRH receptor proteins and associated complexes from biological samples.
• Drug Delivery System Research: Investigated as a potential targeting moiety in conjugate systems for site-specific delivery of therapeutic agents.

Basic Information

Product Name	(Biotinyl-Gln1)-Lhrh
CAS No.	218433-98-8
Molecular Formula	C73H110N20O19S
Molecular Weight	1555.85 g/mol
Synonyms	Biotinyl-Gln1-Luteinizing Hormone-Releasing Hormone; Biotin-Gln1-GnRH; Biotinylated [Gln1]-LHRH; Biotinyl-Gln1-LHRH; Gonadorelin (Gln1), biotinylated; Biotinylated GnRH Analog; LHRH-biotin conjugate; Biotin-LHRH derivative
EINECS	Contact for details

Quality Control

Our (Biotinyl-Gln1)-Lhrh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and diagnostic use. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to relevant industry standards for peptide synthesis, and our quality protocols are designed to meet the stringent requirements of GMP and ISO guidelines for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.