Description

2-Fluoro-6-Iodo-4-Methylbenzenamine is a high-purity, multi-functional halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of fluorine and iodine atoms on the aromatic ring, which enables precise structural modifications and facilitates cross-coupling reactions. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated structure for enhanced bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination.
• Chemical Biology & Proteomics: Utilized as a tagging or labeling reagent for biomolecules due to its reactive amine group and halogen handles.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of complex, halogenated dyes and pigments for high-performance applications.

Basic Information

Product Name	2-Fluoro-6-Iodo-4-Methylbenzenamine
CAS No.	217314-44-8
Molecular Formula	C7H7FIN
Molecular Weight	251.04 g/mol
Synonyms	4-Amino-3-fluoro-5-iodotoluene; 3-Fluoro-5-iodo-4-methylaniline; 2-Fluoro-6-iodo-p-toluidine; 4-Methyl-2-fluoro-6-iodoaniline; 5-Iodo-3-fluoro-4-methylbenzenamine; Benzenamine, 2-fluoro-6-iodo-4-methyl-; 217314-44-8; 2-Fluoro-6-iodo-4-methylaniline
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-Iodo-4-Methylbenzenamine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.