Description

Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) is a synthetic, cyclic pentapeptide integrin antagonist, widely recognized for its high affinity and specificity for the αvβ3 integrin receptor. This compound is a critical research tool for studying cell adhesion, angiogenesis, and tumor metastasis pathways. It is essential for researchers and developers in pharmaceutical R&D, cancer biology, and diagnostic imaging, where precise molecular targeting is required.

Application

• Angiogenesis Research: Used as a potent inhibitor to study the role of αvβ3 integrin in blood vessel formation.
• Cancer Therapeutics Development: Serves as a lead compound or targeting moiety in the development of anti-cancer drugs and drug delivery systems.
• Molecular Imaging: Employed in the synthesis of radiolabeled probes (e.g., with ⁶⁸Ga, ⁹⁹ᵐTc) for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) to visualize tumors.
• Cell Adhesion & Migration Studies: Applied in in vitro assays to investigate integrin-mediated cellular processes.
• Biomaterial Functionalization: Used to coat surfaces to promote or inhibit specific cell attachment for tissue engineering applications.
• Diagnostic Agent Precursor: A key intermediate in the manufacture of targeted diagnostic agents.

Basic Information

Product Name	Cyclo(-Arg-Gly-Asp-D-Tyr-Lys)
CAS No.	217099-14-4
Molecular Formula	C₂₉H₄₅N₁₁O₉
Molecular Weight	667.74 g/mol
Synonyms	c(RGDyK); Cyclo(Arg-Gly-Asp-D-Tyr-Lys); cRGDyK; Cyclo(RGDyK); Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) acetate; c[RGDyK]; c(RGD-D-Tyr-K); αvβ3 Integrin Antagonist, Cyclic RGD Peptide
EINECS	Contact for details

Quality Control

Our Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.