Description

(S)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine Hcl is a high-purity chiral amine building block of significant importance in advanced organic synthesis. This compound is valued for its trifluoromethylated aromatic structure, which imparts unique electronic and steric properties critical for modulating the biological activity and physicochemical profile of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly as a key intermediate in the development of receptor antagonists and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the trifluoromethyl groups enhance lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with specific electronic properties.
• Chemical Biology & Proteomics: Utilized as a building block for activity-based probes and molecular tags in biochemical research.

Basic Information

Product Name	(S)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine Hcl
CAS No.	216002-19-6
Molecular Formula	C10H8F6N·HCl
Molecular Weight	283.63 g/mol (Free base: 247.17 g/mol)
Synonyms	(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine hydrochloride; (S)-α-Methyl[3,5-bis(trifluoromethyl)phenyl]methylamine hydrochloride; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethylamine HCl; (S)-3,5-Bis(trifluoromethyl)phenethylamine hydrochloride; (S)-1-(3,5-Bis(trifluoromethyl)phenyl)ethan-1-amine hydrochloride; (S)-Amphetamine, 3,5-bis(trifluoromethyl)-, hydrochloride; (S)-ATFM-PEA HCl
EINECS	Contact for details

Quality Control

Our (S)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethylamine Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.