Description

Prolactin-Releasing Peptide (1-31) (Human) CAS NO 215510-22-8 is a synthetic 31-amino acid peptide fragment that corresponds to the active N-terminal region of the human prolactin-releasing peptide (PrRP) protein. This compound is a critical research tool for investigating the neuroendocrine regulation of prolactin secretion and its associated physiological and behavioral functions. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on endocrinology, neurobiology, and metabolic disorder research.

Application

• Neuroscientific Research: Used as a specific agonist to study the role of the PrRP receptor (GPR10) in the central nervous system, including its effects on appetite regulation, stress response, and cardiovascular function.
• Endocrine Studies: Essential for in vitro and in vivo experiments to elucidate the mechanisms of prolactin release from the anterior pituitary gland and its feedback loops.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening campaigns to identify novel modulators of the PrRP pathway for potential therapeutic applications.
• Biochemical Assay Development: Employed in the development and validation of immunoassays (e.g., ELISA) and receptor binding assays to quantify PrRP levels or receptor activity.
• Metabolic Disorder Research: Investigated for its potential role in energy homeostasis, making it relevant for research into obesity, diabetes, and related metabolic syndromes.
• Cell Signaling Pathway Analysis: Used to activate specific intracellular signaling cascades (e.g., MAPK/ERK) downstream of GPR10 to study cellular responses.

Basic Information

Product Name	Prolactin-Releasing Peptide (1-31) (Human)
CAS No.	215510-22-8
Molecular Formula	C152H246N46O41S
Molecular Weight	3417.9 g/mol
Synonyms	PrRP (1-31); hPrRP-31; Prolactin-Releasing Peptide, human; GPR10 Ligand; Prolactin Releasing Factor; CARP (C-terminal Amidated Arginine Peptide); hPrRP31; Prolactin-Releasing Hormone Fragment
EINECS	Contact for details

Quality Control

Our Prolactin-Releasing Peptide (1-31) (Human) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical results to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.