Description

Fmoc-D-Styrylalanine CAS NO 215190-23-1 is a high-purity, non-natural amino acid derivative featuring a styryl side chain, protected at the N-terminus with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of peptides with enhanced stability, specific binding properties, or fluorescent labeling potential. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected D-configured amino acid for the automated synthesis of complex peptides.
• Peptidomimetic Drug Discovery: Incorporation into peptide backbones to create metabolically stable analogs with modified pharmacological profiles.
• Fluorescent Peptide Probes: The styryl group can serve as a precursor for conjugation or may exhibit intrinsic fluorescence properties useful in imaging and binding studies.
• Bioconjugation & Protein Engineering: Used to introduce unique chemical handles or hydrophobic motifs into synthetic peptides for downstream labeling or functionalization.
• Academic & Industrial Research: A key reagent in medicinal chemistry and chemical biology for studying protein-protein interactions and enzyme mechanisms.
• Combinatorial Library Synthesis: For generating diverse libraries of peptide-based compounds for high-throughput screening.

Basic Information

Product Name	Fmoc-D-Styrylalanine
CAS No.	215190-23-1
Molecular Formula	C26H23NO4
Molecular Weight	413.46 g/mol
Synonyms	Fmoc-D-2-(4-Vinylphenyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-ethenylphenyl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-vinylphenyl)propanoic acid; Fmoc-D-4-Vinylphenylalanine; Fmoc-D-Phe(4-CH=CH2)-OH; N-Fmoc-D-styrylalanine; D-Fmoc-styrylalanine; Fmoc-D-Styr
EINECS	Contact for details

Quality Control

Our Fmoc-D-Styrylalanine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage. Keep container tightly sealed when not in use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.