Description

Z-D-Dab(Boc)-Oh Dcha CAS NO 214852-61-6 is a protected amino acid derivative, specifically the Dicyclohexylamine (DCHA) salt of Boc-protected D-2,4-diaminobutyric acid. This compound serves as a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering enhanced solubility and handling properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, including antimicrobial peptides and targeted drug conjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the controlled incorporation of D-2,4-diaminobutyric acid residues into peptide chains.
• Antimicrobial Peptide (AMP) Research: For constructing analogs of natural host-defense peptides to study structure-activity relationships and improve stability.
• Peptidomimetic Drug Discovery: Enabling the creation of non-natural peptide-like molecules with enhanced metabolic stability and bioavailability for therapeutic applications.
• Bioconjugation and Linker Chemistry: The free amino group after deprotection can be used to attach payloads, labels, or polyethylene glycol (PEG) chains in antibody-drug conjugates (ADCs) or diagnostic probes.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides for studying protein-protein interactions and cellular pathways.
• Process Development & Scale-Up: Serves as a high-purity intermediate for the GMP manufacturing of peptide-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Z-D-Dab(Boc)-Oh Dcha
CAS No.	214852-61-6
Molecular Formula	C26H41N3O6
Molecular Weight	491.62 g/mol
Synonyms	Nα-Z-Nγ-(tert-Butoxycarbonyl)-D-2,4-diaminobutyric acid dicyclohexylamine salt; (R)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid compound with dicyclohexylamine; Z-D-Dab(Boc)-OH·DCHA; Boc-D-Dab(Z)-OH DCHA salt; D-2,4-Diaminobutyric acid, N2-benzyloxycarbonyl, N4-Boc-, DCHA salt; DCHA salt of Z-D-Dab(Boc)-OH; Nα-Carbobenzyloxy-Nγ-tert-butyloxycarbonyl-D-2,4-diaminobutyric acid dicyclohexylammonium salt.
EINECS	Contact for details

Quality Control

Our Z-D-Dab(Boc)-Oh Dcha is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.