Description

Fmoc-β-(2-Quinolyl)-D-Ala-Oh is a specialized, non-proteinogenic amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound matters as a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise incorporation of a quinoline-containing side chain. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing therapeutic peptides, protease inhibitors, and bioactive molecules targeting specific protein interactions.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Drug Discovery & Medicinal Chemistry: Used to introduce a quinoline pharmacophore into peptide backbones to enhance binding affinity, modulate bioavailability, or create novel protease inhibitors.
• Bioconjugation & Probe Development: Serves as a precursor for synthesizing fluorescent or affinity-labeled peptide probes, leveraging the quinoline moiety's properties.
• Academic & Industrial Research: Essential for studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR) in peptide science.
• Synthesis of Peptidomimetics: Facilitates the creation of peptide-like molecules with improved metabolic stability and membrane permeability for therapeutic applications.

Basic Information

Product Name	Fmoc-β-(2-Quinolyl)-D-Ala-Oh
CAS No.	214852-58-1
Molecular Formula	C₂₈H₂₄N₂O₄
Molecular Weight	452.50 g/mol
Synonyms	Fmoc-β-(2-Quinolyl)-D-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-quinolinyl)-D-alanine; Fmoc-D-3-(2-Quinolyl)alanine; Fmoc-3-(2-Quinolyl)-D-Ala-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(quinolin-2-yl)propanoic acid; N-α-Fmoc-3-(2-quinolyl)-D-alanine; Fmoc-D-2-Quinolylalanine; Fmoc-D-β-(2-Quinolyl)alanine
EINECS	Contact for details

Quality Control

Our Fmoc-β-(2-Quinolyl)-D-Ala-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.