Description

Fmoc-β-(2-Quinolyl)-Ala-OH is a specialized, non-proteinogenic amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a quinoline-containing side chain into peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing quinoline-modified residues.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, where the quinoline moiety can impart specific binding, fluorescence, or catalytic properties.
• Chemical Biology & Proteomics: Serves as a building block for creating peptide probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Material Science: Employed in the synthesis of peptide-based polymers and biomaterials with unique optical or electronic characteristics derived from the quinoline unit.
• Academic Research: Fundamental studies in peptide chemistry, structure-activity relationships (SAR), and the synthesis of non-natural peptide libraries.

Basic Information

Product Name	Fmoc-β-(2-Quinolyl)-Ala-OH
CAS No.	214852-56-9
Molecular Formula	C₂₈H₂₂N₂O₄
Molecular Weight	450.49 g/mol
Synonyms	Fmoc-β-(2-Quinolyl)-alanine; Fmoc-3-(2-Quinolyl)-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(quinolin-2-yl)-L-alanine; Fmoc-L-β-(2-Quinolyl)alanine; Nα-Fmoc-3-(2-quinolyl)-L-alanine; Fmoc-β-(2-Quinoly)Ala-OH; (2S)-3-(quinolin-2-yl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-β-(2-Quinolyl)-Ala-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, MS). A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.